Since the dawn of time, erectile dysfunction has been a problem. Erectile dysfunction once believed to be the reason for having sex with “undesirable” women in 800 BC, is now recognized as a symptom of early-stage heart disease and poor mental state. Lifestyle choices are also a factor.

Let’s look at the infamous origins of the condition and how doctors have managed to treat it over the years, beginning in the 17th century with saline injections.

Early History

Regnier de Graff invented his own solution in 1668, long before online retailers began offering the lowest Tadalafil price online. He was able to induce an erection by injecting saline in the penile blood vessels. This is one of the first “cures” for impotence.

Saline’s use in Peyronie’s Disease

Francois de la Peyronie was the first to use saline for his condition. He used it in 1743. Charles Edouard Brown-Sequard, a French neurologist, was the first to examine the relationship between hormone production and aging.

ED, and the Hormonal Connect

Brown-Sequard conducted animal experiments before injecting animal testicular oil directly into his bloodstream. Modern science has concluded that Brown-Sequard’s positive results were a placebo effect, as the small amount of androgen he administered wouldn’t have any effects on the body.

ED Revolution and Testicle Therapy

Brown-Sequard’s discoveries introduced androgen therapy to medicine, sparking an ED revolution. Many doctors tried to transplant testicles from monkeys and goats into their patients. However, these failed until the penile implant was invented.

Modern History: How the ED Medication Process Changes with Time

There are five known medications that treat ED: penile implants, vacuum devices (vascular surgery), local therapies, oral contraceptives, and penile implants. Let’s see how they have changed.

Penile Implants

1936 saw the first penile implant. Nicolai Bogoras used the bone to restore penile stiffness. It worked for a while, but after several months the bone was absorbed by the body, thereby eliminating its effects. The current permanent malleable implants use silicon rods.

Penile implants are considered the best method for achieving an erection.

They have a 86% success ratio but they can be invasive and complicated and can lead to mechanical failure. They should not be used as a last resort, regardless of their success.

Vacuum Devices

The EricAid vacuum pump is the most popular. It works by applying negative pressure to the penis. This causes an increase in blood circulation. To prolong erection, a cock ring is put around the penis’s base. An erection can take between 2-2.5 minutes and 2-5 minutes.

These devices have been used by many men to maintain an erection with a 74% success rate. It has been criticized for its ineffectiveness and the 30-minute time required for an erection. Many men do not use prescribed pumps which can increase side effects and cause severe phimosis.

Vascular Surgery

The procedure of arterial revascularization surgery restores blood flow to the penis. This can be accomplished by several methods, with varying effectiveness levels ranging from 38-79%. This surgery is rarely recommended by doctors today due to its high success rate and a long list of complications. Doctors recommended cenforce 100 mg Tablet to treat ED in men.

Local Therapies

Alprostadil injections into the penis can be recommended if oral drug therapy is unsuccessful. These injections relax the penile muscles and induce erection. Side effects such as pain are common, but it is possible to reduce the dosage. Intracavernosal drug treatment works in between 75-86% of patients.

Oral Therapy

Sildenafil (Viagra), which was the first oral ED treatment, was discovered at a Pfizer research center in Kent. It was originally used to treat high blood pressure and angina. They discovered that sildenafil caused erections in clinical trials. In 1998, Viagra was approved by the FDA.


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